Bacterial Inclusion Bodies: Discovering Their Better Half
نویسندگان
چکیده
منابع مشابه
Bacterial Inclusion Bodies Contain Amyloid-Like Structure
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Bacterial inclusion bodies (IBs) are refractile aggregates of protease-resistant misfolded protein that often occur in recombinant bacteria upon gratuitous overexpression of cloned genes. In biotechnology, the formation of IBs represents a main obstacle for protein production since even favouring high protein yields, the in vitro recovery of functional protein from insoluble deposits depends on...
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BACKGROUND Bacterial inclusion bodies are submicron protein clusters usually found in recombinant bacteria that have been traditionally considered as undesirable products from protein production processes. However, being fully biocompatible, they have been recently characterized as nanoparticulate inert materials useful as scaffolds for tissue engineering, with potentially wider applicability i...
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Bacterial inclusion bodies are microscopic, ovoid-shaped aggregates of insoluble protein. Under protease exposure a digestion process is produced that reveals a variable fragmentation rate, not compatible with a surfacerestricted erosion of body particles, or an uniform sensibility to the fragmentation agent. The modelling and fitting of experimental data is performed in two steps. (a) Due to p...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2017
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2017.01.005